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KMID : 0378019720150050095
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New Medical Journal
1972 Volume.15 No. 5 p.95 ~ p.102
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Studies on Metabolism of Sugar in the Walker 256 Tumor Animal
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Abstract
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After single injection of 14C-glucose into the Walker 256 tumor animal via tail vein, hourly blood and respiratory samples were collected. Blood and gas samples were analyzed for blood sugar levels, total C02 production rates and their radioactivities.
On the basis of specific activity(SA)-time curves of blood glucose and respiratory C02 in which both SA decreased exponentially with time, glucose pools, glucose spaces, turnover rates of glucose pools and relative specific activities(RSA) were calculated by isotope dilution principle.
Data obtained in the cancer animal group were compared, with the control group as follows:
1) There are little differences in blood sugar levels and values of glucose pools between control and cancer animal group. Accordingly glucose spaces show almost same values which is about 20% of body weight. Thus, there are no change in distribution kinetics of glucose between control and cancer animal group.
2) Turnover rates of glucose pool were 96.9±19.2%/hr. in the control group and 85.4±10.8%/hr. in the cancer animal group. About 12% of the control value was decreased in the cancer animal group. Half time (t2), which are time to turnover the half of glucose pool, increased about 9. 8%
in the cancer animal group as compared with the control value.
3) The total CO2 production rate was a mean of 1.54±0.14 mM/hr. /100 gm. in the control group and 1. 20±0. 07 mM/hr/100 gm. in the cancer animal group. Though the difference in total CO2 production rate between control and cancer animal group was not significant, C02 yield from C14￢glucose was remarkably decreased more than 50% of control value in the cancer animal group, showing 0.09±0.02 mM/hr. /100 gm. in the cancer animal group and 0. 19±0.05mM/hr. /100gm. in the control group. These findings impressed that inhibition of glucose oxidation into C02 in the cancer
animal group caused by local inhibition of glucose oxidation in the cancer tissue but also by general inhibition of glucose oxidation in the intact tissues other than cancer tissue. These possibilities were briefly discussed.
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